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Risk measures in late effect research
• Standardized Incidence Ratio (SIR) =
Observed / Expected numbers of events =
Relative risk compared to general population
-
High SIR for rare event
low absolute risk
• Absolute excess risk (AER) =
Excess number of events beyond expected number / 10,000 persons/ year
• Cumulative incidence = % developing event, accounting for death as a
competing risk
• Hazard ratio = RR for treatment A vs treatment B