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Risk measures in late effect research

• Standardized Incidence Ratio (SIR) =

Observed / Expected numbers of events =

Relative risk compared to general population

-

High SIR for rare event

low absolute risk

• Absolute excess risk (AER) =

Excess number of events beyond expected number / 10,000 persons/ year

• Cumulative incidence = % developing event, accounting for death as a

competing risk

• Hazard ratio = RR for treatment A vs treatment B