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Multivariable regression analysis

Cox model adjusted for sex and age. HR = Hazard ratio; 95% CI = 95% confidence interval

4.2 g/m

2

procarbazine≈3x MOPP or 6 MOPP-ABV(D)

CRC

Transverse colon

& rectum

Risk Factor

HR

95% CI

HR

95% CI

Treatment

Procarbazine

No CT or CT without procarbazine

1.0

Reference

1.0

Reference

CT, ≤ 4.2g/m

2

procarbazine

1.7

0.7-4.4

1.8

0.6-6.0

CT, > 4.2g/m

2

procarbazine

2.7

1.4-5.2

3.6

1.5-8.6

Radiotherapy

No infradiaphragmatic RT

1.0

Reference

1.0

Reference

Infradiaphragmatic RT

1.8

1.0-3.2

2.2

1.0-4.7