311 / 1498
Incidence
• 5% of all HL
• 1.5 / 1m population/ y
• Recently recognized category:
– 1944:
Jackson & Parker: granuloma variant of HL
– 1994:
REAL classification (CD20+ LP, L&H/ popcorn cells)
– 2001:
WHO (separated from cHL as NLP)
• No prospective studies:
– Re-analysis of previous studies
– Institutional / registry based retrospective studies