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stage I/II Hodgkin lymphoma is associated with an increased risk of
early relapse: Clinical results of the preplanned interim analysis of the
randomized EORTC/LYSA/FIL H10 trial.
Raemaekers JM
,
et al; J Clin Oncol. 2014 Apr 20;32(12):1188-94
• A
nalysis included 1,137 patients.
- Favorable subgroup - 85.8% negative early PET scan
- Unfavourable subgroup - 74.8% negative early PET scan
• IDMC concluded unlikely to show non-inferiority in the final results for the
experimental arm and advised stopping random assignment for early PET-
negative patients
.
• CONCLUSION: CMT resulted in fewer early progressions in clinical stage I/II HL,
although early outcome was excellent in both arms. The final analysis will reveal
whether this finding is maintained over time.