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Conclusions for FDG PET in Early HL
• Using FDG PET may be possible to identify a group of patients with an excellent
“early” outcome from chemotherapy alone
• EORTC H10 trial – failed to achieve this goal
– Favorable subgroup: 14.2% positive early PET scan
• UK NCRI RAPID results were achieved in the setting of
– Very conservative definition of PET negative 25.3 % PET positive
– Quality controlled PET image acquisition / Central review of PET images at the Core
Lab
– What is the QA like in your routine clinical practice ?
• Longer follow-up is required to establish the impact of a PET negative approach
on 10 and 20 year survival and cause of death