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RT in Advanced-Stage HL
•
The prevailing wisdom:
No role for RT after full dose
chemotherapy
•
The dominant study:
CALGB/GELA published NEJM 2003
•
The resulting recommendation:
ABVD X6-8 or escalated
BEACOPPX8-6
•
The concern:
1.
Long or intense chemotherapy
with higher toxicity
2. Sub-optimal disease control, higher
need for salvage, inferior survival