424 / 1498
R
A
N
D
O
M
I
Z
E
ABVD (n=404)
6-8 CYCLES
MODIFIED IFRT 36 Gy ONLY TO
PATIENTS WITH MASSIVE
MEDIASTINAL DISEASE
STANFORD V (n=408)
12 WEEKS CHEMOTHERAPY
MODIFIED IFRT 36 Gy TO SITES
>5 CM IN MAXIMUM
TRANSVERSE DIMENSION
n=854
n=812 eligible
A Randomized Phase III Trial of ABVD Vs. Stanford V +/- Radiation Therapy In
Locally Extensive and Advanced Stage Hodgkin's Lymphoma: An Intergroup
Study Coordinated by the Eastern Cooperative Oncology Group (E2496)
Gordon L et al. JCO 2013