Flipping Book - Hema

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of Salvage for Hodgkin Lymphoma
1985-2015
• First Generation (1985-1994): 146 pts.
• Various salvage therapy
• Pre-transplant IF-RT
• TLI+CV or CBV/BMT
• Second Generation (1994-1998): 81 pts.
• Intent to treat analysis
• ICE salvage therapy
• IF-RT
• TLI+CV or CBV/ASCT
• Third Generation (1998- 2004): 105 pts.
• Risk-adapted program
• Same principles as 2nd
• Fourth Generation (2004- 2009 98 pts.
• Achieve minimal disease state pre-ASCT
• Add GND if PET remains positive
• Same risk-related concept
• Fifth Generation (2011-2014)
– Brentuximab followed by ICE—ISRT + STLI – ASCT 45 pts.
•
ATHERA trial post-transplant BV maintenance (2010-2014) .
Total = 475 pts.