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It is intrinsic or extrinsic radiosensitivity?
Image from:
J Clin Invest.
2012
; 122(10):3424-3431. doi
: 10.1172/JCI63186 .Step 1. The DNA of the tumor cell
is targeted by IR…
Step 2. Tumor cell sustains DSBs
and “responds” to this damage
Step 3a. Apoptosis ensues
Step 3b. Microenvironment influences survival
These are NOT
mutually exclusive
Factors!