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Materials and Methods: Our

Approach

TheYale/MSK LymphomaGEP Collaboration

Create p tient database

for low grade lymphomas

Analyze patterns of local control

after RT, and select outlier cases

Perform (FFPE) gene expression profiling

Search for predictive gene signatures

Validate in the entire cohort

Extract RNA from archival (FFPE*) specimens

*FFPE=Formalin-fixed, paraffin-embedded tissue