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What about ABVD needs improving?
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Bleomycin lung toxicity with ABVD
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Efficacy of ABVD is decreased in certain subgroups
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In patients with stage III/IV disease, the 5-year FFS is about 65%
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In patients >60 years, the 5-year FFS is poor
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In patients with IPS 3-7, the 5-year FFS is about 65%
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Long-term tumour control of 70% not good enough
Improve efficacy!