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How can we improve BEACOPP

escalated

?

Early mortality

sAML/MDS

Infertility

Organ toxicity

linked to dose-intensity and Kairos

principle, not to a specific drug

cyclophosphamide, etoposide,

procarbazine

cyclophosphamide,

procarbazine

bleomycin

: lung,

vincristine

: PNP,

steroids

: infections