85 / 1498
•
Untreated DLBCL
•
Aged > 60 years
8 x R-CHOP
8 x CHOP
R
A
N
D
O
M
I
S
E
D
CHOP:
Cyclophosphamide 750 mg/m²
Doxorubicin 50 mg/m²
Vincristine 1.4 mg/m²
Prednisone 40 mg/m²/day x 5 days
R-CHOP: Rituximab 375 mg/m
2
Day 1 of each cycle
Cycles every 21 days
GELA LNH-98.5: Trial design
Coiffier B,
et al. Blood
2010; 116:2040–2045.