1002 / 1708
High-dose chemotherapy (HDT) with busulfan/melphalan (Bu-
Mel) may yield benefits for patients suffering from metastasized
Ewing tumors compared with conventional chemotherapy
In late 2003, there was an alert concerning severe complications after BuMel
HDT and irradiation of the spinal cord
Subsequently an amendment with a restriction of the radiation dose to the spinal
cord of 30 Gray (Gy) after BuMel HDT and a warning regarding radiotherapy to central axial
sites following BuMel HDT was established within the study protocol
In 2005, two reports from France described severe gut toxicity after BuMel HDT and high
dose radiotherapy in the pelvis
Absence of severe toxicity problems in Germany