1007 / 1708
Second malignancies after Ewing's sarcoma: radiation
dose-dependency of secondary sarcomas.
Kuttesch et al, J Clin Oncol, 1996
-SJCRH Data base including 266 survivors of Ewing's sarcoma: 16
second malignancies (6.0%) (median follow-up 9.5 years)
- Median latency to the diagnosis of the second malignancy = 7.6
years (range, 3.5 to 25.7).
- The
cumulative incidence rate of secondary sarcoma was
radiation dose-dependent
(P = .002):
•
no secondary sarcomas in children with Ewing’s sarcoma who
received dose <48 Gy.
•
the absolute risk of developing a secondary sarcoma after
doses of 48–59.99 Gy was 24.9 cases/10,000 person-years; for
doses of 60 Gy, it was 131 cases/10,000 person-years