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Summary and conclusions
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ES are the second most frequent primary bone cancer, affecting
primarily patients in the second and third decades of life
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Patients presenting with localized disease have an approximately
two thirds chance of being cured
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Those whose disease is initially systemic have a much worse
outcome (30-40% EFS rate with isolated pulmonary mets, less
than 20% chance of cure with bone or bone marrow involvement)
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No chance of cure in relapsing patients
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New therapeutic approaches required to cure refractory diseases
and/or to reduce late effects