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Wilms Tumor
Stage I, Favorable Histology
NWTS-1
• Radiotherapy not necessary for Group 1 Wilms’ tumor < 2 years of
age
• There was a benefit for radiotherapy for Group 1 Wilms’ tumor > 2
years of age (2 yr DFS: 77% vs. 58%, p = 0.04). These pts were
treated with Regimen A (AMD alone)
NWTS-2
• Radiotherapy not used in Group I patients. VCR was added to
regimen. Randomization was 6 mos vs. 15 mos. Of AMD + VCR. 3-
yr RFS was 89% and 84% respectively
D'Angio GJ et al. Cancer 1976,
D'Angio et al. Cancer 1981