1164 / 1708
RT for high risk localized RT
Studies
n
Dose
Fractionation
Volume
Relapse rate
Local/metasta
sis/both/total
Wolden et al.
IJROBP 2000
Kushner et al.
JCO 2001
99
21Gy
1.5Gy BID Extent of tumor at diagnosis
+ 3 cm + lymph nodes
10/45/55
Laprie et al.
Cancer 2004
32
24 Gy or 34 Gy
1.5Gy/day
Preoperative volume + 2cm 0/0/1/1
Haas-kogan et al.
IJROBP 2003
31
10 Gy TBI + 10 Gy
or 20 Gy
2 Gy/Day
Preoperative volume + 2cm 22% failure
rate
Bradfield et al.
Cancer 2004
17
21 Gy +/- 9Gy
1.5 Gy/day
Preoperative volume + 2cm 1/6/0/7
Ducassou et al, Strahlen
Onkol 2015
35
24 Gy or 34 Gy
1.5 Gy/day
Preoperative volume + 2cm 69% local
control at 15
years
Casey et al,
ASTRO 2016
246
21Gy
1.5 Gy/day
3%local
failure at 5
years