paediatrics Brussels 17

1536 / 1708

A
GENE Cohort
PFS
P= .02
0.25
0.50
0.75
1.00
0 1 2 3 4 5 6 7 8 9 10
Time Since Diagnosis (years) Time Since Diagnosis (years)
PFS (probability)
GTR
STR
175128 89 70 54 48 40 34 25 18 15
87 50 36 23 16 13 10 8 7 6 4
GTR
STR
No. at risk
St Jude’s Cohort
P= .007
0.25
0.50
0.75
1.00
0 1 2 3 4 5 6 7 8 9 10
Time Since Diagnosis (years)
PFS (probability)
84 82 70 59 58 56 51 43 40 36 33
20 17 13 11 10 9 7 7 6 3 2
GTR
STR
No. at risk
GTR
STR
C
OS
P< .001
0.25
0.50
0.75
1.00
0 1 2 3 4 5 6 7 8 9 10
OS (probability)
176148123101 79 67 54 48 39 29 22
87 58 50 38 34 22 17 13 11 9 7 STR
GTR
No. at risk
GTR
STR
B
P= .003
0.25
0.50
0.75
1.00
0 1 2 3 4 5 6 7 8 9 10
Time Since Diagnosis (years)
OS (probability)
84 84 80 75 73 71 65 55 51 44 39
20 19 19 15 12 11 10 10 9 6 4
GTR
STR
No. at risk
GTR
STR
D
F
P= .2
0.25
0.50
0.75
1.00
0 1 2 3 4 5 6 7 8 9 10
Time Since Diagnosis (years)
OS (probability)
49 48 43 39 33 31 24 19 13 9 7
37 35 30 27 24 21 17 12 9 7 6
GTR
STR
No. at risk
GTR
STR
E
CERN Cohort
P = .06
0.25
0.50
0.75
1.00
0 1 2 3 4 5 6 7 8 9 10
Time Since Diagnosis (years)
PFS (probability)
49 48 43 39 33 31 24 19 13 9 7
37 35 30 27 24 21 17 12 9 7 6
GTR
STR
No. at risk
GTR
STR
H
P= .01
0.25
0.50
0.75
1.00
0 1 2 3 4 5 6 7 8 9 10
Time Since Diagnosis (years)
OS (probability)
114105 88 71 59 49 40 35 19 16 11
97 88 73 54 41 29 20 11 8 7 5
GTR
STR
No. at risk
GTR
STR
G
Burdenko Cohort
P< .001
0.25
0.50
0.75
1.00
0 1 2 3 4 5 6 7 8 9 10
Time Since Diagnosis (years)
PFS (probability)
114 92 68 51 42 32 26 22 12 10 7
98 67 46 29 17 13 7 5 5 5 4
GTR
STR
No. at risk
GTR
STR
Fig 2. (A, C, E, and G) Progression-free
survival (PFS) and (B, D, F, and H) overall
survival (OS) of EPN_PFA stratified by extent
of resection across all four cohorts. CERN,
Collaborative Ependymoma Research Net-
work; GENE, Global Ependymoma Network
of Excellence; GTR, gross total resection;
STR, subtotal resection (. 5 mm residual
disease). P values determined using log-
rank test.
© 2016 by American Society of Clinical Oncology 5
Treatment of Posterior Fossa Ependymoma Subgroups
from 139.18.224.1
Information downloaded from and provided by at UNIVERSITAETSKLINIKUM LEIPZIG on June 20, 2016
Copyright © 2016 American S ciety of Clinical Oncology. All rights reserved.