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Outcome according to RT volume
Author
Outcome after
Local RT
Craniospinal RT
Goldwein et al 1990
31% 5-year PFS
27% 5-year PFS
Vanuytsel et al 1992
38% 5-year PFS
46% 5-year PFS
Rousseau et al 1994
40% 5-year EFS
49% 5-year EFS
Stuben et al 1997
58% 5-year PFS
45% 5-year PFS
Mc Laughlin et al 1998
1/17 Leptomeningeal
relapses
0/15 Leptomeningeal
relapses
Oya et al 2002
3/37 Leptomeningeal
relapses
1/10 Leptomeningeal
relapses
Pattern of relapse:
local relapses predominantly!
Merchant et al., 2002: 5/6 relapses occurred locally
No impact of CSI on relapse rate!