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SIOP Ependymoma II

FINAL Protocol

Version 1.2_November 14th, 2013

MRI obtained immediately before radiotherapy should be used

for treatment planning.

To properly delineate target volumes for this study

, complete information

defining the extent of disease before and after surgery is needed.

Pre- and post-operative MRI, in particular

pre- and post-gadolinium contrast T1, T2, and FLAIR sequences

,

should be reviewed. Sequences that best define post-operative

tumour bed and residual disease at each time point should be

utilized to define the GTV and registered to planning CT.

Target definition and margins