390 / 1708
Hyperfractionated Radiotherapy (HIT-SIOP PNET 4)
340 children (age 4 to 21 years) with
standard-risk medulloblastoma
randomized to hyperfractionated
RT (36 Gy CSI, 60 Gy whole
posterior fossa, 68 Gy tumor bed
at 1 Gy BID) and conventional
RT (23.4 Gy, 54 Gy whole
posterior fossa at 1.8 Gy daily)
8 cycles of cisplatin, lomustine and
vincristine
Lannering B et al. J Clin Oncol 2012; 30:3187-93
Severe hearing loss was not different
In the two groups