392 / 1708
POG9031: High-Risk Medulloblastoma
112 patients randomized to
each arm
35.2 Gy-40 Gy CSI
3 cycles of CDDP and VP-
16 prior to XRT or XRT
followed by the same
chemotherapy. Both
received consolidative
vincristine and
cyclophosphamide
Five-year EFS:66% (Chemo
first arm) and 70% (XRT
first arm), p=0.54
Tarbell NJ et al. J Clin Oncol 2013; 31:2936-41