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Tumor Pathology
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Embryonal – most common, head and neck and genitourinary
sites
•
Sarcoma botryoides (cluster of grapes) – subtype of embryonal,
better prognosis, tend to occur in cavities (head and neck, bile
duct, vagina, bladder)
•
Spindle cell – subtype of embryonal, better prognosis,
paratesticular and head and neck sites
•
Alveolar – worse prognosis, extremity and perineal sites, nodal
metastasis worse
•
Pleomorphic – rare in children, described in adult population
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Undifferentiated sarcoma – unfavorable histology, used to be
included in Intergroup Rhabdomyosarcoma Studies now in
COG NRSTS protocols