755 / 1708
Randomized Trial IRS-IV
•
No difference in local failure between conventional and
hyperfractionated arms
•
Acute toxicity (mucositis 66% vs. 46% p = 0.03) for
parameningeal sites (nausea and vomiting 13% vs. 5% p =
0.02) (skin reactions 16% vs. 7% p = 0.03) and non-
parameningeal head and neck sites were increased in
hyperfractionated arm
•
Incidence of local failure (13%) = distant failure (13%)
•
Standard of care for Group III RMS is conventional
radiotherapy with chemotherapy
Donaldson SS et al. Int J Radiat Oncol Biol Phys 2001; 51:718-
28