797 / 1708
COG ARST1431
•
Dose escalation to 59.4 Gy for tumors > 5 cm at initial
diagnosis
•
Cone down after 36 Gy is allowable for residual disease
•
In the case of complete response (CR) by imaging (MRI/CT
and PET-CT or negative biopsy), 36 Gy is allowed
•
In delayed primary excision, dose de-escalation is allowed: 36
Gy for negative margins and 41.4 Gy for positive margins