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GTV1, CTV1, and PTV1 are defined

45 Gy in 1.8 Gy are delivered based on pre-chemo extent

GTV2 defined as residual visible or palpable tumor by

imaging or physical exam

For unresected or partially resected tumors, GTV2 includes

pre-treatment abnormalities in bone and gross tumor in soft

tissue post-chemo

CTV2=GTV2 + 1 cm

PTV2 = 10.8 Gy for total of 55.8 Gy

Post-op RT: 50.4 Gy for R1 and 55.8 Gy for R2

Radiation Dose – Current COG Protocol