102 / 220
Table
1.
Summary and Comparison of Baseline Characteristics Between Total Thyroidectomy
+
Prophylactic Central Neck Dissection (Group A)
and Total Thyroidectomy Alone (Group B)
No.
of patients
No. of central
LNs excised
Incidence of
central LNM (%)
First author (country)
A B
Mean age at
operation (years)
Sex ratio
(male:female)
Mean tumor
size (mm)
ETE (%)
Multifocality
(%)
No significant difference
a
between A and B
A B
A
B
Roh (Korea) (17)
40 73
A
=
na
B
=
48.5
A
=
na
B
=
9:64
A
=
na
B
=
22
A
=
na
B
=
30.1
A
=
na
B
=
15.1
1,2,3,4,5
5.6 na
62.2
na
Choi (Korea) (18)
48 53
A
=
52
B
=
48
A
=
6:42
B
=
11:42
A
=
6.8
B
=
7.3
A
=
45.8
B
=
58.5
A
=
31.3
B
=
22.6
1,2,3,4,5
na
na
37.5
na
Bardet (France) (19)
36 161
na
na
na
na
na
na
na
na
23.5
na
Perrino (Italy) (20)
92 159
na
na
na
na
na
na
na
na
33–52
na
Costa (Italy) (21)
126 118
A
=
46
B
=
52
A
=
26:100
B
=
24:94
A
=
17
B
=
15
na
A
=
45.2
B
=
40.7
2,4,5
na
na
46.8
5.1
Zuniga
(Columbia) (22)
136 130
A
=
42.9
B
=
41.5
A
=
10:126
B
=
13:117
na
A
=
44.8
B
=
27.3
A
=
38.2
B
=
13.1
1,2,3
na
na
82.4
na
Moo (United States) (23)
45 36
A
=
45.7
B
=
49.2
A
=
10:35
B
=
4:32
A
=
14
B
=
20
A
=
24.4
B
=
36.1
A
=
55.6
B
=
63.9
1,2,4,5
8.8 1.7
33.3
na
Hughes (United States) (24)
78 65
A
=
46.8
B
=
41.2
A
=
17:61
B
=
16:49
A
=
19
B
=
20
A
=
41.0
B
=
16.9
A
=
33.3
B
=
33.8
1,2,3,5
6.0 0.0
61.5
9.2
Popadich (Australia,
United States, and
United Kingdom) (25)
259 347
A
=
44
B
=
48
A
=
52:207
B
=
81:266
A
=
23
B
=
22
A
=
27.8
B
=
24.2
A
=
48.3
B
=
42.7
2,3,4,5
6.8 0.35
49.0
0.9
So (Korea) (26)
119 113
A
=
49.2
B
=
49.8
A
=
21:98
B
=
16:97
A
=
6.6
B
=
6.2
A
=
51.3
B
=
51.3
A
=
37.8
B
=
23.9
1,2,3,4
na
na
37.0
na
Lang (China) (7)
82 103
A
=
52.0
B
=
50.0
A
=
18:64
B
=
22:81
A
=
15
B
=
10
A
=
26.8
B
=
14.6
A
=
36.6
B
=
27.2
1,2,5
5
0
54.9
4.9
Wang (United States) (27)
49 37
na
na
s
na
na
na
9
na
40.8
na
Raffaelli (Italy) (28)
124 62
A
=
42.7
B
=
43.2
A
=
24:100
B
=
13:49
A
=
12.9
B
=
12.1
na
A
=
51.6
B
=
46.8
1,2,3,5
9.6 1.5
35.5
9.7
Barczynski
(Poland) (29)
358 282
na
A
=
75:283
B
=
60:222
na
A
=
13.1
B
=
12.8
A
=
37.7
B
=
35.1
1,2,4,5
6.7
na
na
na
a
Matching: 1
=
age; 2
=
sex ratio; 3
=
tumor size; 4
=
extrathyroidal extension; 5
=
tumor multifocality.
s, significantly different (
p
<
0.05) between groups A and B; ns, not significantly different between groups A and B; na, not available or specified; LN, lymph node; LNM, lymph node metastasis;
ETE, extrathyroidal extension.
82