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V.
Lymphatic System: Sentinel Node Biopsy
Agrawal A, Civantos FJ, Brumund KT, et al. [
(99m)
Tc]Tilmanocept accurately detects sentinel
lymph nodes and predicts node pathology status in patients with oral squamous cell
carcinoma of the head and neck: results of a phase III multi-institutional trial.
Ann Surg
Oncol
. 2015; 22(11):3708-3715. EBM level 1.............................................................105-112
Summary
: Sentinel lymph node biopsy using [99mTc]tilmanocept accurately predicted nodal status in
oral cavity head and neck
squamous cell carcinoma with a low false-negative rate, high negative
predicative value, and high accuracy. This study demonstrates this may be a method used in
conjunction with or in lieu of elective neck dissection, but future studies are warranted.
Durham AB, Lowe L, Malloy KM, et al. Sentinel lymph node biopsy for cutaneous
squamous cell carcinoma on the head and neck.
JAMA Otolaryngol Head Neck Surg
. 2016;
142(12):1171-1176. EBM level 4..................................................................................113-118
Summary
: This study conducted a retrospective review of sentinel lymph node biopsy in cutaneous
squamous cell carcinoma. Analysis by serial step sectioning and immunohistochemistry increased the
sentinel lymph node biopsy positivity rate to 15.1%.
Mehta V, Nathan CA. What is the role of sentinel lymph node biopsy in early-stage oral
cavity carcinoma?
Laryngoscope
. 2016; 126(1):9-10. EBM level 4...........................119-120
Summary
: This paper presents a review of the role of
sentinel lymph node biopsy in early-stage oral
cavity carcinoma.
Schilling C, Stoeckli SJ, Haerle SK, et al. Sentinel European Node Trial (SENT): 3-year
results of sentinel node biopsy in oral cancer.
Eur J Cancer
. 2015; 51(18):2777-2784. EBM
level 2..............................................................................................................................121-128
Summary
: This is a prospective study of sentinel lymph node biopsy in oral cancer. The results show
excellent sensitivity, positive predicative value, and survival when employed for oral cancer.
VI.
Quality of Life
Reeve BB, Cai J, Zhang H, et al. Factors that impact health-related quality of life over time
for individuals with head and neck cancer.
Laryngoscope
. 2016; 126(12):2718-2725. EBM
level 4..............................................................................................................................129-136
Summary
: This study is a population-based longitudinal cohort study which attempts to identify
sociodemographic, behavioral, and clinical factors associated with health-related quality of life
(HRQOL) for head and neck cancer patients over time by administering a questionnaire at baseline, 22
months, and 42 months. Its strength is the largenumber of patients (587).
Rettig EM, D'Souza G, Thompson CB, et al. Health-related quality of life before and after
head and neck squamous cell carcinoma: analysis of the Surveillance, Epidemiology, and End
Results-Medicare Health Outcomes Survey linkage.
Cancer
. 2016; 122(12):1861-1870.
EBM level 4....................................................................................................................137-146
Summary
: Quality of life (QOL) for older individuals with head and neck squamous cell carcinoma
was examined using the SEER database. The records of 1653 patients were examined. The authors
noted that QOL declines both before and after head and neck squamous cell carcinoma, and any
observed posttreatment recovery is likely an artifact of shorter survival among individuals with the
lowest QOL.