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IX.
Inflammatory: GERD Role in Cancer Development and Prevention
Busch EL, Zevallos JP, Olshan AF. Gastroesophageal reflux disease and odds of head and
neck squamous cell carcinoma in North Carolina.
Laryngoscope
. 2016; 126(5):1091-1096.
EBM level 3....................................................................................................................182-187
Summary
: This study is a large population case-control study of head and neck cancer in North
Carolina. The authors found no increased odds of head and neck cancer with self-reported heartburn
symptoms or self-reported medical diagnosis of gastroesophageal reflux disease. These results held
true for subgroup analysis for specific tumor sites as well.
Papagerakis S, Bellile E, Peterson LA, et al. Proton pump inhibitors and histamine 2 blockers
are associated with improved overall survival in patients with head and neck squamous
carcinoma.
Cancer Prev Res (Phila)
. 2014; 7(12):1258-1269. EBM level 3..............188-199
Summary
: This is a large prospective cohort of head and neck squamous cell carcinoma patients in
which histamine receptor-2 antagonists (H2RAs) and proton pump inhibitor (PPI) use and treatment
outcomes were examined. The findings demonstrated that both medications were significant
prognostic factors for overall survival ,but that only H2RAs were associated with recurrence-free
survival in HPV16-positive oropharyngeal squamous cell carcinoma patients.