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Marks LB, et al. Use of normal tissue complication probability models in the clinic.
Int. J. Radiat. Oncol. Biol. Phys. 2010 (76-3): S10-S19.
1.
n
value is function of the structure:
Lung
Spinal cord
2. Within a structure
n
can be function of the effect:
Proctitis (Rectum)
Dementia (Brain)
Rectal Bleeding (Rectum)
Necrosis (Brain)
3. Within a structure
n
can be function of the anatomy
The Volume Effect in OAR
(
)
(
)
n
irradiated
reference
reference
irradiated
V
V
VD
VD
⋅
=