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How to consider the volume effect in
dose-response models?
•
Probit
:
Lyman
•
Logistic
(log
dose
):
Niemierko
50
4
50
1
1
γ
+
=
D
D
NTCP
∞−
−
=
t
x
dx e
NTCP
2
2
2
1
π
(
)
π
γ
2
50
50
50
⋅
− =
D
DD t
a
j
a
j
j
Dv
EUD
1
1
=
=