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Summary
•
Small dose differences make a difference (clinically)
(MR linac)
(Proton Beam Therapy)
•
Keep talking – dialogue = 2 way conversation
•
Multi-criteria optimisation (MCO) – improved individualisation
•
More data needed on normal tissue toxicity dose response
•
Dose accumulation – VoxTox
Needs automatic OAR segmentation & other computing
•
Biological variation in normal tissue sensitivity
Could we convolve a
biological
measure of individual
normal tissue radiosensitivity with the
physical
dose plan