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Do you believe pain or other symptoms originating from

non-bone need higher doses?

A.

Yes, because there is usually a larger mass that needs

higher dosage

B.

Yes, because because the cellular mechanisms are

different

C.

No, in principle, single doses should be as efficient as in

bone mets

D.

No, the philosophy is the same, for pain single doses, for

large masses higher doses

E.

No, it depends on life expectancy; < 3 months single

dose, > 3 months higher doses