155 / 604
Systemic treatments prevents bone events
Reduce skeletal related events (SREs)
Fracture, surgical intervention, need for radiotherapy, SCC
- Increase bone mass / strength
- No effect on pain
Porta- Sales et al, Pall Med 2016
•
Bisphosphonates
- Oral
- IV
•
RANK-L inhibitors
- Denosumab sc 1 per month
Peddi et al, Canc Treat Rev 2013
•
Ra 223
- Phase 3 ALSYMPCA study, prostate cancer, n= 921
- Outcome 33% SRE vs. 38%
- Time to first SRE 15,6 vs. 9,8 months
Sartor et al, Lancet Oncol 2014
15-sep-16
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