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How to set the Clinical tolerance limit (

TL

D

)?

Clinical tolerance limits or specifications should be based on

clinical experience.

Clinical experience can be summarized through statistical

analysis of the outcome of a particular treatment for a

particular tumor disease.

Examples:

Local tumor control as a function of dose.

Fraction of survivors after five years as a function of

dose.

At the same time, normal tissue complications must be

taken into account.

From Jörgen Olofsson (Dose Modeling and dose verification ESTRO COURSE)