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How cancers evolve?
•
Cancer cells constantly accrue a variety of genetic alterations
•
Subclones
arising from
founder clones
show heterogeneity in their
genetic makeup
•
Cancer cells are exposed to a variety of selection pressures induced by
decreased blood supply, hypoxia, and treatment-related effects
•
Resulting selection and expansion of
subclones
with genetic makeup
that is ideal for continued survival
Devarakonda S, Ann Oncol 2017