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Factors influencing choice of ablative modality

Need for tissue (mutations, PDL1 expression, liquid biopsies)

Location (brain, bone/vertebra, liver, liver hilus, central lung)

Size of lesion (>3 cm cutoff)

Previous treatments (high-dose radiation, surgery)

Co-morbidities, patient preferences, institutional experience

Timing (phased treatments, initial systemic therapy)

Enhancement of immune function (SABR)

Senan S, ESMO 2017