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„Targeted“

S Y S T E M I C

Therapy

„ Targeted“

L O C A L

Therapy

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ESTRO SBRT COURSE 2017 - Matthias Guckenberger

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Rational for combining SRT and targeted

drugs

Ø

Promising field for pre-clinical and clinical research

Locally recurrent disease

Re-irradiation

(Oligo)-metastasis

(Oligo)-progression

Symtomatic metastases

Ø

Radiosensitizer to

decrease RT-induced

toxicity

Ø

Eradication of oligo-

resistant clones

Ø

Immune modulation

Ø

Long term palliation

Ø

Symptom prevention

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ESTRO SBRT COURSE 2017 - Matthias Guckenberger

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