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Is 1 respiration correlated 4D-CT representative for the

actual treatment?

Repeated 4D-CTs

during

the treatment course

Second 4D-CT after > 2 fractions (median 6 days):

No systematic changes of motion pattern and target volume

Target coverage compromised in one patient (atelectasis)

Repeated 4D CBCT scans (median 9) during RT:

Stable trajectory with variability (1SD) less than 1mm

Significant base-line shifts

Continuous tumor tracking in EPID images:

Stable tumor trajectory, both intra-fractional and inter-fractional

Sonke IJROBP 2008

No benefit of replanning because of motion variability

Haasbeck IJROBP 2007

Richter IJROBP 2010

Imaging for target definition: RC-CT

SBRT 2017 - D. Verellen