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Tissue heterogeneity &

dose prescription

The problem is that with the evolution of more accurate or different dose

calculations, the reported doses using one system are not always comparable to

doses obtained with another (

SBRT lung as a case in point!!

).

e.g. recent protocol for a randomized trial: hypofractionated SBRT versus surgery for

IA NSCLC:

ROSEL DOSE PRESCRIPTION

(Hurkmans

et al.

, Radiat Oncol 2008)

For type A dose calculation models: 3 x 20 Gy

For type B dose calculation models: 3 x 18 Gy

Pencil Beam versus Monte Carlo Dose Calculation

SBRT 2017 - D. Verellen

Type A

Type B