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Tissue heterogeneity &
dose prescription
•
The problem is that with the evolution of more accurate or different dose
calculations, the reported doses using one system are not always comparable to
doses obtained with another (
SBRT lung as a case in point!!
).
•
e.g. recent protocol for a randomized trial: hypofractionated SBRT versus surgery for
IA NSCLC:
ROSEL DOSE PRESCRIPTION
(Hurkmans
et al.
, Radiat Oncol 2008)
For type A dose calculation models: 3 x 20 Gy
For type B dose calculation models: 3 x 18 Gy
Pencil Beam versus Monte Carlo Dose Calculation
SBRT 2017 - D. Verellen
Type A
Type B