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With open beams (non-IMRT), things are “reasonably” simple

Ø

The high dose more or less follows the dense tissue

But what about IMRT, VMAT?

Ø

If a homogeneous coverage of the PTV is prescribed, the IMRT

optimization will artificially boost the fluence to the air inside the PTV

Ø

What if GTV and OAR move inside these area’s?

SBRT 2017 - D. Verellen

PTV &

tissue heterogeneity &

dose prescription

Courtesy M. Guckenberger