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With open beams (non-IMRT), things are “reasonably” simple
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The high dose more or less follows the dense tissue
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But what about IMRT, VMAT?
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If a homogeneous coverage of the PTV is prescribed, the IMRT
optimization will artificially boost the fluence to the air inside the PTV
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What if GTV and OAR move inside these area’s?
SBRT 2017 - D. Verellen
PTV &
tissue heterogeneity &
dose prescription
Courtesy M. Guckenberger