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ESMO Guidelines [Vansteenkiste J, Ann Oncol 2014]

“pre-treatment pathological diagnosis strongly recommended in all patients

before

any curative treatment

, unless a multidisciplinary tumour board (MDT)

is of the opinion that the risk-benefit ratio of the procedure is unacceptable.

Treatment without pathology

Expert MDT’s best placed to assess likelihood of benign disease in their

populations including, where available,

algorithms

validated for the

population in question. In case of the latter, a

likelihood of malignancy

exceeding 85%

may be preferred”.