Framebased-Frameless_DV_2017

Lindberg K, WCLC 2016

74 patients (42 in arm A, 31 in arm B)

21 patients (28%) experienced grade 3-5 side

effects (

atrioventricular block, bleeding, dyspnea,

empyema, fatigue, fever, fistula, lung infection, pain,

pneumonitis, pneumothorax and ventricular arrhythmia

)

7 patients experienced G5 toxicity (6 in group A)

6 patients experienced G5 hemoptysis

G4-5 side effects occurred more frequently in

group A than in group B (19% vs 3%)

Nordic - HILUS study

8 x 7 Gy prescribed to 65-70% isodose line

Moderately central vs ‘ultracentral’ tumors

A: close to a main bronchus

B: close to a lobar bronchus