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Aetiology of hepatocellular
carcinoma
•
Risk factors
–
Alcoholic cirrhosis in the western world
–
Hepatitis B (HBV) and C (HCV) in Asia and Africa
–
Haemochromatosis, Wilson’s disease and other congenital diseases
–
Aflatoxin (
Aspergillus
)
–
Obesity; non-alcoholic steatohepatitis (NASH) – in the western world
70-90% of all HCC cases are based on chronic liver disease or cirrhosis
•
Protective factors
–
Reduce/eliminate alcohol consumption
–
Antiviral therapy
–
Healthy lifestyle