S389
ESTRO 36
_______________________________________________________________________________________________
Results of the test were validated in 72% of the patients.
They were confirmed by histology in 14%, by another
imaging technique (MRI, Bone scintigraphy or CT) in 23.2%,
by another 18F-Ch-PET in 5% and with a biochemical
response after a specific treatment in 48% of them. Result
of the test was discordant in 9%. According to this data,
18F-Ch-PET has a Sensibility and Specificity of 97% and 81%
respectively.
Conclusion
18F-Ch-PET seems to be a very useful diagnostic test for
restaging recurrent PCa in selected group of patients,
allowing all relapse sites to be evaluated at once.
It can also modify treatment management in an important
percentage, identifying which ones can be offered a
potential curative treatment.
In our series, like in previous literature, PSA level, PSAvel
and PSAdt are strong predictive factors for positive 18F-
Ch-PET.
PO-0739 Phase II Trial of Dynamic Dosimetry for
prostate brachytherapy: correlation with post-implant
MRI/CT
Abstract withdrawn
Poster: Clinical track: Skin cancer / malignant
melanoma
PO-0740 Surgery versus Radiotherapy in Uveal
Melanoma: SEER Analysis using Propensity Score
Matching &IPTW
B.S. Jang
1
, J.H. Chang
2
, S.H. Oh
3
, Y.J. Lim
1
, I.H. Kim
4
1
Seoul National University Hospital, Department of
Radiation Oncology, Seoul, Korea Republic of
2
SMG-SNU Boramae Medical Center, Department of
Radiation Oncology, Seoul, Korea Republic of
3
SMG-SNU Boramae Medical Center, Department of
Biostatistics, Seoul, Korea Republic of
4
Cancer Research Institute- Seoul National University
College of Medicine, Department of Radiation Oncology,
Seoul, Korea Republic of
Purpose or Objective
The treatment of uveal melanoma includes surgery and
radiotherapy (RT). Utilization of RT has been increasing as
a strategy for organ preservation, but the survival
difference between two modalities has not been reported.
Material and Methods
Patients diagnosed with uveal melanoma from 2004 to
2013 were selected from Surveillance, Epidemiology, and
End Results (SEER) database. Propensity-score matching
with nearest neighbor 1:1 matching method and inverse
probability of treatment weighting (IPTW) using
propensity score were used to compare the survival
outcome between RT only and surgical resection alone for
the treatment of uveal melanoma.
Results
Overall, 3,291 patients were treated: 2,503 received RT
only (RT group) and 788 surgical resections only (surgery
group), respectively. After propensity-score matching,
437 patients were identified in each cohort (total N = 874).
The RT group had an improved crude 5-year overall
survival (OS) rate compared with the surgery group (76 %
vs. 60 %, P-value < 0.001) and the 5-year cancer-specific
survival (CSS) rate (89% vs. 72 %, P-value < 0.001),
respectively. Compared to the surgery group, the RT group
was associated with improved OS [hazard ratio (HR) =
0.51, 95% confidence interval (CI) = 0.39 – 0.66, P-value <
0.001] and CSS [HR = 0.37, 95% CI = 0.25 - 0.54, P-value <
0.001] in multivariate Cox proportional hazard analysis,
respectively. The survival benefit of the RT group
maintained after adjustment with IPTW, both in OS
[adjusted HR (AHR) = 0.45, 95% CI = 0.36 - 0.56, P-value <
0.001] and CSS [AHR = 0.27, 95% CI 0.27 - 0.51, P-value <
0.001].
Conclusion
To our knowledge, the present study is the first to
demonstrate the survival difference according to the
treatment modality in uveal melanoma, using both
propensity-score matching and weighting methods with
the SEER database. The current study suggests that RT
might provide a survival advantage over surgery in the
treatment of uveal melanoma.
PO-0741 Ipilimumab and stereotactic radiosurgery
with cyberknife in melanoma brain metastases
V. Borzillo
1
, R. Di Franco
1
, S. Falivene
1
, A. Martino
2
, V.
Ravo
1
, G. Totaro
1
, F.M. Giugliano
3
, P.A. Ascierto
4
, A.M.
Grimaldi
4
, L. Festino
4
, E. Simeone
4
, V. Vanella
4
, F.
Cammarota
1
, D. Giannarelli
5
, P. Muto
1
1
Istituto Nazionale Tumori Fondazione Pascale,
Radioterapia, Napoli, Italy
2
Seconda Università degli Studi di Napoli, Dipartimento
di Diagnostica per Immagini e Radioterapia, Napoli, Italy
3
European Medical Imaging Fondazione Muto-onlus,
Radiation Oncology, Casavatore- Naples, Italy
4
Istituto Nazionale Tumori Fondazione Pascale, Struttura
Complessa Oncologia Medica Melanoma Immunoterapia
Oncologica e Terapie Innovative, Napoli, Italy
5
Istituto Nazionale Tumori Regina Elena Roma,
Biostatistical Unit, Roma, Italy
Purpose or Objective
Ipilimumab(Ipi), an anti-cytotoxic T-lymphocyte-
associated antigen
4(CTLA-4) monoclonal antibody, has
been shown to improve survival in patients(pts) with
advanced melanoma. However, there is a lack of data
about the efficacy of Ipi in pts with brain metastases(BMs),
as well as about its combination with radiotherapy(RT) and
the right sequence of both treatments. The purpose of this
study was
to evaluate overall survival(OS), local
control(LC)
of
the
lesion
treated,
and
intracranial control(IC) in pts with melanoma BMs (MBMs)
treated with
stereotactic
Radiotherapy(SRT)/radiosurgery(SRS) with Cyberknife®
and Ipi
Material and Methods
From December 2012 to May 2016 we treated 63 pts(34
M,29 F) with MBMs. The median age was 61 years (28-81y).
52pts received Ipi: 24 prior-RT(IPI PRE-RT), 7 concomitant-
RT and 21 post-RT(IPI POST-RT).11 not received Ipi(NO