ESTRO 36 Abstract Book

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S597 ESTRO 36
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chronic toxicities, disease status and overall survival at 2
years were compared between conventional 2DRT and
IMRT. Treatment related toxicities were reported using
physician rated RTOG acute and late toxicity criteria.
Results
58 patients who were treated with conventional 2DRT and
56 patients who were treated with IMRT for locally
advanced HNSCC between 2012 and 2014 were chosen for
comparative analysis. The 2DRT arm consisted of 45% of
stage III and 55% of stage IV patients whereas the IMRT arm
had 27% and 73% of them respectively. In the 2DRT arm
53% and 47% had grade 2 and 3 acute mucositis where as
in the IMRT arm it was 80% and 5% respectively. This
difference reached statistical significance (p<0.001). But,
acute skin toxicity was only marginally higher in the 2DRT
arm than the IMRT arm.
In the 2DRT arm 84% had grade 2 and 3 acute xerostomia
while in the IMRT arm it was 45% and this difference
reached statistical significance (p=0.004). Likewise, the
difference remained statistically significant (p=0.01) with
chronic xerostomia evaluated at 1 year post treatment
with an incidence of 76% in the 2DRT arm and 38% in the
IMRT arm.
It was observed that the treatment break due to acute
radiation reactions were more in the 2DRT arm (16%) than
in the IMRT arm (9%), however this did not reach statistical
significance. However, these two modalities showed no
significant differences in response to CRT and loco-
regional control or survival at 2 years.
Conclusion
IMRT significantly reduces the incidence and severity of
acute mucositis and acute and chronic xerostomia when
compared with conventional 2DRT in the treatment of
locally advanced HNSCC. However, IMRT did not show
superiority over 2DRT with respect to response to CRT,
locoregional control and survival at 2 years.
EP-1086 Health status and phisical activity in head and
neck cancer survivors
A. Matías-Pérez1, G. Gallego-Herreros1, B. G. Díaz de
Tudanca1, P. Soria-Carreras1, A. Nieto-Palacios 1, A.
Rodríguez-Gutierrez1, L.A. Pérez-Romasanta1
1Hospital Universitario de Salamanca, Radiation
Oncology Department, Salamanca, Spain
Purpose or Objective
Head and Neck (H&N) cancer survivors are an increasingly
population, due to the improvement in diagnosis and
treatment. The aim of this study is to analyse the health
status and physical activity in H&N cancer survivors in a
single institution.
Material and Methods
The population was composed of a series of 50 H&N cancer
patients survivors (>3 years post-diagnosis) treated in our
institution from 2006 to 2013, having no signs of cancer
recurrence to the date. They were reviewed based on
personal interviews and specific questionnaires. The
health status items measured were: nutritional
assessment (with the Body Mass Index (BMI), the
Malnutrition Universal Screening Tool (MUST) and the
Subjective Global Assessment (SGA)), cardiovascular risk
(with the HeartScore® tool), toxic habits (tobacco and
alcohol by the Alcohol Use Disorders Identification Test
(AUDIT)) and physical activity (with the Global Physical
Activity Questionnaire(GPAQ)).
Results
The mean age was 64 years (range, 43-84 years) and 46
patients (92%) were male. The most frequent site of the
primary tumour was larynx (48%) and the main histology
squamous cell carcinoma (76%). 72% of patients had
advanced cancers (stages III and IV), whereas 26% had
stages I and II. All patients received radiotherapy, of which
31 patients (62%) were given 3DRT technique and 19
patients (38%) IMRT technique. Surgery was performed in
17 patients (34%), and 20 patients (40%) underwent neck
dissection. The most part of our population had
overweight (BMI 27 ± 3). The MUST score showed that 7
patients (14%) were at high risk of malnutrition, and
regarding SGA, 12 patients (24%) were suspected of
malnutrition. Cardiovascular risk was high or very high in
12 (24%) and 19 (19%) patients, respectively. Taking into
account toxic habits, 6 patients (12%) were active
smokers, while 38 (76%) were ex-smokers. AUDIT score
showed that 3 (6%) were risk drinkers and 3 (6%) had
problems related with alcohol abused. 86% of the patients
accomplished WHO recommendations of physical exercise.
Conclusion
Our study indicates that head and neck cancer survivors
could have clinical issues regarding health status, and
efforts should be done to identify these patients,
especially those with risk of malnutrition, high
cardiovascular risk or toxic habits, in order to offer the
best clinical care.
EP-1087 Real-world Cetuximab toxicity in curative
and recurrent/metastatic setting in HNSCC patients.
I. Desideri1, C. Muntoni1, C. Ciabatti1, M. Lo Russo1, P.
Bonomo1, M. Loi1, D. Greto1, I. Meattini1, L. Livi1
1University of Florence, Radiotherapy, Firenze, Italy
Purpose or Objective
Observational monocentric study to assess, in patients
affected by head and neck squamous cell carcinomas
(HNSCC), the acute toxicity of Cetuximab (CTX)
administered concurrently with radiotherapy (RT) in the
curative setting, or as a chemotherapy (CT) in patients
with recurrent/metastatic disease.