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Summary

Experience with IMRT and IGRT continues to grow.

IGRT:

provides explicit information to moderate uncertainties.

is currently limited to simple on-line interventions

must evolve to support more complex interventions

IGRT requires further development

Accumulate statistical models of organ movement and setup error.

Reduce time and effort required for re-planning

Planning and IGRT:

Adaptive control (driven by model-based feedback)

Robust control (driven by statistical models of uncertainty)

Incorporation of robust criteria reduces effort; e.g. replanning.

Formal methods for balancing trade-offs in control design