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Summary 1:
What is the necessary SBRT dose to achieve local control?
-
BED >100 Gy
(3x15Gy, 4x12Gy, 5x10Gy, 8x7.5Gy)
- still
dose effect
beyond
-
larger tumors
may benefit from higher doses for LC
but have higher risk of distant spread
- negative effect of long treatment
duration
(<>11d)
however, high-dose-CFRT/AFRT outcome comparable
risk for
toxicity
in SBRT for central tumors:
►
more fractionated
regimes
Question 2:
What are the normal tissue constraints?
22 · 22. Januar 2016