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German Cancer Consortium (DKTK)
SUMMARY NORMAL TISSUES
Although the LQ model may be applicable also to the SBRT situation,
there is no really solid quantification on dose effect relations on NT
toxicity after high biological doses, especially in the mediastinum
Therefore, at this moment it is extremely difficult to give serious
recommendations on NT restrictions in the hypofractionated situation
While toxicity for peripheral SBRT seems better predictable, for
central tumors we may encounter unpleasant surprises with
increasing uncritical use of the method
Prospective data on dose/volume/effect relations from well controlled
clinical trials are urgently needed